Publications

Komiyama NH, van de Lagemaat LN, Stanford LE, Pettit CM, Strathdee DJ, Strathdee KE, Fricker DG, Tuck EJ, Elsegood KA, Ryan TJ, Nithianantharajah J, Grant SGN (2020). Synaptic combinatorial molecular mechanisms generate repertoires of innate and learned behavior.

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Nguyen HT, Dobbyn A, Charney AW, Bryois J, Kim A, Mcfadden W, Skene NG, Huckins LM, Wang W, Ruderfer DM, Xu X, Fromer M, Purcell SM, Lage K, Stahl EA (2020). Integrative analysis of rare variants and pathway information shows convergent results between immune pathways, drug targets and epilepsy genes.

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Byrne EM, Zhu Z, Qi T, Skene NG, Bryois J, Pardinas AF, Stahl E, Smoller JW, Rietschel M, Owen MJ, Walters JT, O’Donovan MC, McGrath JG, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (2020). Conditional GWAS analysis identifies putative disorder-specific SNPs for psychiatric disorders.

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Nathan Skene (2020). Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson’s disease. Nature Genetics.

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Nathan Skene (2020). Conditional GWAS analysis to identify disorder-specific SNPs for psychiatric disorders.. Molecular psychiatry.

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Jansen IE, Savage JE, Watanabe K, Bryois J, Williams DM, Steinberg S, Sealock J, Karlsson IK, Hägg S, Athanasiu L, Voyle N, Proitsi P, Witoelar A, Posthuma D (2019). Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk.. Nature genetics.

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Jansen PR, Watanabe K, Stringer S, Skene N, Bryois J, Hammerschlag AR, de Leeuw CA, Benjamins JS, Muñoz-Manchado AB, Nagel M, Savage JE, Tiemeier H, Posthuma D (2019). Genome-wide analysis of insomnia in 1,331,010 individuals identifies new risk loci and functional pathways.. Nature genetics.

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Coleman JRI, Bryois J, Gaspar HA, Jansen PR, Savage JE, Skene N, Plomin R, Muñoz-Manchado AB, Linnarsson S, Crawford G, Hjerling-Leffler J, Breen G (2019). Biological annotation of genetic loci associated with intelligence in a meta-analysis of 87,740 individuals.. Molecular psychiatry.

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X. Qian, K.D. Harris, T. Hauling, D. Nicoloutsopoulos, A.B. Muñoz-Manchado, N. Skene, J. Hjerling-Leffler, M. Nilsson (2019). Probabilistic cell typing enables fine mapping of closely related cell types in situ. Nature Methods.

Nathan Skene (2019). Genome-wide analysis identifies molecular systems and 149 genetic loci associated with income. Nature Communications.

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Zeisel A, Hochgerner H, Lönnerberg P, Johnsson A, Memic F, van der Zwan J, Häring M, Braun E, Borm LE, La Manno G, Codeluppi S, Furlan A, Lee K, Linnarsson S (2018). Molecular Architecture of the Mouse Nervous System.. Cell.

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Muñoz-Manchado AB, Bengtsson Gonzales C, Zeisel A, Munguba H, Bekkouche B, Skene NG, Lönnerberg P, Ryge J, Harris KD, Linnarsson S, Hjerling-Leffler J (2018). Diversity of Interneurons in the Dorsal Striatum Revealed by Single-Cell RNA Sequencing and PatchSeq.. Cell reports.

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Zhu F, Cizeron M, Qiu Z, Benavides-Piccione R, Kopanitsa MV, Skene NG, Koniaris B, DeFelipe J, Fransén E, Komiyama NH, Grant SGN (2018). Architecture of the Mouse Brain Synaptome.. Neuron.

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Savage JE, Jansen PR, Stringer S, Watanabe K, Bryois J, de Leeuw CA, Nagel M, Awasthi S, Barr PB, Coleman JRI, Grasby KL, Hammerschlag AR, Posthuma D (2018). Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence.. Nature genetics.

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Harris KD, Hochgerner H, Skene NG, Magno L, Katona L, Bengtsson Gonzales C, Somogyi P, Kessaris N, Linnarsson S, Hjerling-Leffler J (2018). Classes and continua of hippocampal CA1 inhibitory neurons revealed by single-cell transcriptomics.. PLoS biology.

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Marcia Roy, Oksana Sorokina, Nathan Skene, Clémence Simonnet, Francesca Mazzo, Ruud Zwart, Emanuele Sher, Colin Smith, J Douglas Armstrong, Seth GN Grant (2018). Proteomic analysis of postsynaptic proteins in regions of the human neocortex. Nature neuroscience.

Nathan G Skene, Julien Bryois, Trygve E Bakken, Gerome Breen, James J Crowley, Héléna A Gaspar, Paola Giusti-Rodriguez, Rebecca D Hodge, Jeremy A Miller, Ana B Muñoz-Manchado, others (2018). Genetic identification of brain cell types underlying schizophrenia. Nature genetics.

Skene NG, Roy M, Grant SG (2017). A genomic lifespan program that reorganises the young adult brain is targeted in schizophrenia.. eLife.

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Mats Nagel, Philip R Jansen, Sven Stringer, Kyoko Watanabe, Christiaan A de Leeuw, Julien Bryois, Jeanne E Savage, Anke R Hammerschlag, Nathan Skene, Ana B Munoz-Manchado, others (2017). GWAS Meta-Analysis of Neuroticism (N= 449,484) Identifies Novel Genetic Loci and Pathways. bioRxiv.

Nathan Skene (2017). E-MTAB-3256 - Transcription profiling by array of wild type mouse hippocampi from 186 animals of both genders and two background strains (C57Bl/6 and 129s5) between the ages of 58 to 600 days.

Nathan Skene, Seth Grant (2016). Identification of Vulnerable Cell Types in Major Brain Disorders Using Single Cell Transcriptomes and Expression Weighted Cell Type Enrichment. Frontiers in Neuroscience.

Anna E Skrzypiec, Rahul S Shah, Emanuele Schiavon, Eva Baker, Nathan Skene, Robert Pawlak, Mariusz Mucha (2013). Stress-induced lipocalin-2 controls dendritic spine formation and neuronal activity in the amygdala. PloS one.

Marcelo P Coba, Noboru H Komiyama, Jess Nithianantharajah, Maksym V Kopanitsa, Tim Indersmitten, Nathan G Skene, Ellie J Tuck, David G Fricker, Kathryn A Elsegood, Lianne E Stanford, others (2012). TNiK is required for postsynaptic and nuclear signaling pathways and cognitive function. The Journal of Neuroscience.